2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus

Joint EULAR/ACR 2019 SLE classification criteria establishing positive ANA (at least once) as an obligatory entry criterion, then additive weighted clinical and immunologic domains with classification at >=10 points. Candidate notes: Positive ANA at least once is an obligatory entry criterion for classification. Additive weighted criteria then apply across seven clinical and three immunological domains (weights 2-10). Patients accumulating >=10 points are classified as SLE (when findings not better explained by another condition). Validation cohort sensitivity 96.1% and specificity 93.4% for the new criteria. ARUP Consult summary of these criteria specifies ANA titer >=1:80 on HEp-2 cells or an equivalent positive ANA test (ever) as the entry criterion. Limits noted in the record: Classification criteria for research/standardization, not a clinical diagnostic algorithm alone; full text paywalled here—core claims from EuropePMC abstract, with >=1:80 detail corroborated on ARUP Consult SLE page. Author list truncated. A positive ANA is not a diagnosis. Claims in this record are not verified.

A positive ANA is not a diagnosis. Claims in this record are not verified.

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