Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective

ICAP consensus paper on clinical relevance of 29 distinct HEp-2 IIFA patterns. Goes beyond binary positive/negative ANA to discuss titer/intensity and pattern-guided follow-up testing in the context of suspected disease. Candidate notes: HEp-2 IIFA provides titer/fluorescence intensity and patterns involving nucleus, cytoplasm, and mitotic cells—not only a dichotomous positive/negative result. Presents ICAP consensus on clinical relevance of 29 distinct HEp-2 IIFA patterns. Clinical relevance is defined primarily in the context of suspected disease and includes recommendations for follow-up testing. Intended to help clinicians use pattern information in daily practice and to inform diagnostic/classification criteria. Limits noted in the record: Full text paywalled here; findings from verified EuropePMC abstract (PMID 30862649). A positive ANA is not a diagnosis. Claims in this record are not verified.

A positive ANA is not a diagnosis. Claims in this record are not verified.

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