High concomitance of disease marker autoantibodies in anti-DFS70/LEDGF autoantibody-positive patients with autoimmune rheumatic disease

Screening 500 patients with autoimmune rheumatic disease found only 22 anti-DFS70-positive; 18 of them also had disease-marker autoantibodies. Consistent with anti-DFS70 being present in about 10% of healthy individuals but only a tiny fraction of ARD patients, patients with only anti-DFS70 are rarely diagnosed with ARD. Candidate notes: Anti-DFS70 found in ~10% of healthy individuals but only a tiny population of ARD patients 22/500 ARD patients anti-DFS70 positive; 18/22 also had disease-marker autoantibodies (anti-dsDNA, anti-cardiolipin, anti-SS-A) All 7 anti-DFS70-positive SLE patients fulfilled SLE classification criteria even excluding the ANA finding Limits noted in the record: Single-center study (Nagoya, Japan) with a small anti-DFS70-positive sample (n=22) Observational design: associations reported, not causal claims A positive ANA is not a diagnosis. Claims in this record are not verified.

A positive ANA is not a diagnosis. Claims in this record are not verified.

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