Longitudinal anti-nuclear antibody (ANA) seroconversion in systemic lupus erythematosus: a prospective study of Swedish cases with recent-onset disease

Prospective longitudinal study of 54 Swedish recent-onset SLE patients with yearly follow-up over 0-96 months, examining whether IF-ANA status and titer change over time and how seroconversion relates to disease course. Candidate notes: 13% (7/54) of initially ANA-positive recent-onset SLE patients lost ANA positivity over time Homogeneous (AC-1; 46%) and speckled (AC-4 or 5; 31%) were the most common patterns at inclusion; 7% switched pattern at least once during follow-up Levels of anti-Sm/RNP, but not anti-dsDNA, correlated with clinical disease activity (mSLEDAI-2K) Limits noted in the record: Small single-country cohort (n=54) of Swedish patients; limited ethnic diversity Authors note the clinical and mechanistic relevance of ANA seroconversion remains uncertain A positive ANA is not a diagnosis. Claims in this record are not verified.

A positive ANA is not a diagnosis. Claims in this record are not verified.

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